Damiati Laila, Eales Marcus G, Nobbs Angela H, Su Bo, Tsimbouri Penelope M, Salmeron-Sanchez Manuel, Dalby Matthew J
Centre for the Cellular Microenvironment, University of Glasgow, Glasgow, UK.
Institute of Molecular, Cell and Systems Biology, University of Glasgow, Glasgow, UK.
J Tissue Eng. 2018 Aug 2;9:2041731418790694. doi: 10.1177/2041731418790694. eCollection 2018 Jan-Dec.
Titanium (Ti) plays a predominant role as the material of choice in orthopaedic and dental implants. Despite the majority of Ti implants having long-term success, premature failure due to unsuccessful osseointegration leading to aseptic loosening is still too common. Recently, surface topography modification and biological/non-biological coatings have been integrated into orthopaedic/dental implants in order to mimic the surrounding biological environment as well as reduce the inflammation/infection that may occur. In this review, we summarize the impact of various Ti coatings on cell behaviour both in vivo and in vitro. First, we focus on the Ti surface properties and their effects on osteogenesis and then on bacterial adhesion and viability. We conclude from the current literature that surface modification of Ti implants can be generated that offer both osteoinductive and antimicrobial properties.
钛（Ti）作为骨科和牙科植入物的首选材料发挥着主导作用。尽管大多数钛植入物取得了长期成功，但由于骨整合失败导致无菌性松动的过早失效仍然很常见。最近，表面形貌修饰和生物/非生物涂层已被整合到骨科/牙科植入物中，以模拟周围的生物环境，并减少可能发生的炎症/感染。在这篇综述中，我们总结了各种钛涂层在体内和体外对细胞行为的影响。首先，我们关注钛表面特性及其对骨生成的影响，然后关注细菌粘附和活力。我们从当前文献中得出结论，钛植入物的表面改性可以实现，同时具备骨诱导和抗菌特性。
