Whishaw I Q, Cassel J C, Majchrzak M, Cassel S, Will B
LNBC-U.P.R. 419 du CNRS, Université Louis Pasteur, Strasbourg, France.
Hippocampus. 1994 Oct;4(5):577-82. doi: 10.1002/hipo.450040507.
Rats with damage to the hippocampal formation and allied structures are hyperactive in many test situations but the cause of this hyperactivity is not known. Here the activity of control rats and rats with fimbria-fornix lesions is documented in tests of overnight activity. Details of activity are then characterized from video recordings of behavior in an open field. Rats with fimbria-fornix lesions make significantly more stops of shorter duration and thus more individual trips than control rats but they do not differ in the distance traveled on individual trips or in travel speed. It is suggested that the main difference between fimbria-fornix rats and control rats is that when fimbria-fornix rats stop they remain "still" for shorter durations than do control rats. This finding is discussed in relation to a theory of locomotor/exploratory behavior, and in relation to its implications with respect to the performance of fimbria-fornix rats in studies of learning and memory.
海马结构及相关结构受损的大鼠在许多测试情境中表现出多动，但这种多动的原因尚不清楚。在此，对照大鼠和穹窿海马伞损伤大鼠的活动情况在夜间活动测试中被记录下来。然后，通过对旷场行为的视频记录来描述活动细节。穹窿海马伞损伤的大鼠比对照大鼠有更多明显更短时长的停顿，因此有更多单独行程，但它们在单独行程中的行进距离或行进速度上并无差异。有人提出，穹窿海马伞损伤大鼠与对照大鼠之间的主要差异在于，穹窿海马伞损伤大鼠停顿期间保持“静止”的时长比对照大鼠短。这一发现结合运动/探索行为理论进行了讨论，并探讨了其对穹窿海马伞损伤大鼠在学习和记忆研究中表现的影响。
