Rekhter M D, Sesorov V V, Mironov A A
Arkh Patol. 1993 May-Jun;55(3):46-50.
Structure of rabbit carotid artery and aorta after their wrapping with synthetic tube was investigated using light and scanning electron microscopy. Periarterial manipulations lead to the development of myointimal thickening covered with endothelium. Surface of the thickening consisted of rhythmically intermitted elevations and pits situated across the long axis of the vessel. Polymorphism of the covering endothelium was observed. Non-random pattern of the subendothelial smooth muscle cells location (connected with hemodynamic changes) was the main cause of formation of rhythmic structures. Structure of intimal thickening in rabbit arteries is similar to that of human aortic intima at early stages of atherogenesis (before lipid accumulation). This model may be used for studying the mechanisms of atherogenesis as well as for pharmacological investigations.
使用光学显微镜和扫描电子显微镜研究了用合成管包裹后的兔颈动脉和主动脉的结构。动脉周围操作导致内膜下增厚并覆盖有内皮。增厚部位的表面由沿血管长轴排列的有节律的间断隆起和凹陷组成。观察到覆盖的内皮具有多态性。内皮平滑肌细胞位置的非随机模式（与血流动力学变化有关）是形成节律性结构的主要原因。兔动脉内膜增厚的结构与人类动脉粥样硬化早期（脂质积累之前）主动脉内膜的结构相似。该模型可用于研究动脉粥样硬化的机制以及进行药理学研究。
