在使青霉素结合蛋白2′（PBP2'）产量最大化的条件下，第四代头孢菌素FK-037对耐甲氧西林金黄色葡萄球菌的活性

Activity of the fourth generation cephalosporin FK-037 against methicillin-resistant Staphylococcus aureus under conditions maximizing PBP2' production.

作者信息

Hamilton-Miller J M

机构信息

Department of Medical Microbiology, Royal Free Hospital, School of Medicine, London, UK.

出版信息

Eur J Clin Microbiol Infect Dis. 1994 Dec;13(12):1053-5. doi: 10.1007/BF02111826.

DOI:10.1007/BF02111826

PMID:7889967

Abstract

To investigate the in vitro activity of the fourth generation cephalosporin FK-037, MICs were determined for 80 strains of methicillin-resistant Staphylococcus aureus from 11 countries. Methicillin and cefamandole served as comparators. The method ensured good expression of PBP2' by use of a large inoculum, salt supplement and incubation for 48 hours at 30 degrees C. FK-037 was twice as active as cefamandole against both strains with high-level and strains with low-level methicillin resistance (geometric mean MICs 23.4 and 10.8 mg/l, respectively).

摘要

为研究第四代头孢菌素FK-037的体外活性，测定了来自11个国家的80株耐甲氧西林金黄色葡萄球菌的最低抑菌浓度（MIC）。以甲氧西林和头孢孟多作为对照。该方法通过使用大量接种物、补充盐分并在30℃孵育48小时，确保了PBP2'的良好表达。FK-037对高水平和低水平耐甲氧西林菌株的活性均为头孢孟多的两倍（几何平均MIC分别为23.4和10.8mg/l）。