FK-037、头孢吡肟、头孢曲松、头孢他啶和头孢呋辛体外活性的多中心比较。
Multicenter comparison of in vitro activities of FK-037, cefepime, ceftriaxone, ceftazidime, and cefuroxime.
作者信息
Washington J A, Jones R N, Gerlach E H, Murray P R, Allen S D, Knapp C C
机构信息
Cleveland Clinic Foundation, Ohio 44195.
出版信息
Antimicrob Agents Chemother. 1993 Aug;37(8):1696-700. doi: 10.1128/AAC.37.8.1696.
Abstract
In a multicenter study, the MICs of FK-037 for 90% of the strains tested (MIC90s) were < or = 1 microgram/ml for members of the family Enterobacteriaceae other than Citrobacter freundii, Enterobacter spp., and Serratia marcescens. Activity against Pseudomonas aeruginosa was variable, with a MIC50 and a MIC90 of 4 and 32 micrograms/ml, respectively. Relative to cefepime, however, FK-037 was less active against ceftazidime-resistant isolates of Enterobacter cloacae. The MIC90 of FK-037 for methicillin-resistant staphylococci was > 16 micrograms/ml.
摘要
在一项多中心研究中，对于弗氏柠檬酸杆菌、肠杆菌属和粘质沙雷氏菌以外的肠杆菌科成员，FK-037对90%受试菌株的最低抑菌浓度（MIC90）≤1微克/毫升。其对铜绿假单胞菌的活性各不相同，MIC50和MIC90分别为4微克/毫升和32微克/毫升。然而，相对于头孢吡肟，FK-037对阴沟肠杆菌头孢他啶耐药菌株的活性较低。FK-037对耐甲氧西林葡萄球菌的MIC90>16微克/毫升。
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