Ryan I P, Tseng J F, Schriock E D, Khorram O, Landers D V, Taylor R N
University of California, San Francisco.
Fertil Steril. 1995 Apr;63(4):929-32.
To investigate the presence of interleukin-8 (IL-8), a macrophage-derived angiogenic factor, in peritoneal fluid (PF) of women with and without endometriosis.
Case-control study.
University hospital.
Eighteen women with laparoscopic findings of mild to severe endometriosis, and nine women with no visual evidence of pelvic pathology.
Peritoneal fluid IL-8 levels were determined using an ELISA. Interleukin-8 concentrations were compared among women with and without endometriosis. Correlation between PF IL-8 concentration and endometriosis stage was investigated.
Interleukin-8 was detectable in the PF of a majority of women (67%). Interleukin-8 concentrations were higher in the PF of women with endometriosis than in matched normal controls. A significant correlation between PF IL-8 concentration and endometriosis stage was noted.
We hypothesize that IL-8 is an important angiogenic factor that contributes to the pathogenesis of endometriosis by promoting the neovascularization of ectopic endometrial implants.
研究巨噬细胞衍生的血管生成因子白细胞介素-8（IL-8）在有和没有子宫内膜异位症的女性腹腔液（PF）中的存在情况。
病例对照研究。
大学医院。
18例经腹腔镜检查发现有轻度至重度子宫内膜异位症的女性，以及9例无盆腔病变视觉证据的女性。
使用酶联免疫吸附测定法（ELISA）测定腹腔液IL-8水平。比较有和没有子宫内膜异位症的女性之间的白细胞介素-8浓度。研究腹腔液IL-8浓度与子宫内膜异位症分期之间的相关性。
大多数女性（67%）的腹腔液中可检测到白细胞介素-8。子宫内膜异位症女性的腹腔液中白细胞介素-8浓度高于匹配的正常对照组。腹腔液IL-8浓度与子宫内膜异位症分期之间存在显著相关性。
我们推测IL-8是一种重要的血管生成因子，通过促进异位子宫内膜植入物的新生血管形成，在子宫内膜异位症的发病机制中起作用。
