Bohuslavizki K H, Hänsel W, Kneip A, Koppenhöfer E, Niemöller E, Sanmann K
Institute of Physiology, University of Kiel, Germany.
Gen Physiol Biophys. 1994 Aug;13(4):309-28.
The actions of psoralens, benzofurans, acridinons and coumarins on the ionic currents in intact myelinated nerve fibres were investigated. All 6 substances blocked the potassium currents in a time-dependent manner, producing so-called K+ transients. Only 5-methoxypsoralen is a largely selective blocker of predominantly the axolemmal potassium channels, which is the characteristic required by our previously proposed working hypothesis for the mechanism of potassium-channel blockers in demyelinating diseases, in particular multiple sclerosis. If the observed K+ transients were to arise by blocking of the potassium channels of the Schwann cell, that is, by the periaxonal accumulation of K+ and a resulting collapse of the electromotive driving force for potassium-ions, according to a modified version of our previous hypothesis the other substances tested could also have a beneficial effect on the impaired impulse conduction in demyelinated axons. In this case a large number of new potential drugs would be available for the symptomatic therapy of MS.
研究了补骨脂素、苯并呋喃、吖啶酮和香豆素对完整有髓神经纤维离子电流的作用。所有6种物质均以时间依赖性方式阻断钾电流，产生所谓的K +瞬变。只有5-甲氧基补骨脂素主要是轴膜钾通道的选择性阻滞剂，这是我们先前提出的脱髓鞘疾病，特别是多发性硬化症中钾通道阻滞剂机制的工作假设所要求的特征。如果观察到的K +瞬变是通过阻断施万细胞的钾通道而产生的，即通过轴周K +的积累以及由此导致的钾离子电动势驱动力的崩溃，根据我们先前假设的修改版本，其他测试物质也可能对脱髓鞘轴突中受损的冲动传导产生有益影响。在这种情况下，将有大量新的潜在药物可用于MS的对症治疗。
