Wright J E
Environ Health Perspect. 1976 Apr;14:127-32. doi: 10.1289/ehp.7614127.
Insect growth regulators (IGRs) are a class of new chemicals that interfere with maturation and reproduction in insects. Proposed hypotheses on the biochemical mechanism of action are presented herein. The environmental aspects as metabolism in soils, plants, insects, and animals suggest strongly that these chemicals undergo rapid degradation and metabolism to innocuous metabolites. The toxicological properties determined for registration of the IGR methoprene, isopropyl (E,E)-11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate, reflected no significant effects against any of the species tested. Toxicological evaluations in swine, sheep, hamsters, rats, dogs, rabbits, guinea pigs, and cattle revealed no clinical signs of toxicosis. Additionally, teratological studies in swine, sheep, hamsters, rats, and rabbits also resulted in no observable effects in the animals at the levels administered.
昆虫生长调节剂（IGRs）是一类干扰昆虫成熟和繁殖的新型化学物质。本文提出了关于其生化作用机制的假设。在土壤、植物、昆虫和动物中的代谢等环境方面强烈表明，这些化学物质会迅速降解并代谢为无害的代谢产物。为昆虫生长调节剂烯虫酯（异丙基（E,E）-11-甲氧基-3,7,11-三甲基-2,4-十二碳二烯酸酯）登记所确定的毒理学特性表明，对任何受试物种均无显著影响。在猪、羊、仓鼠、大鼠、狗、兔子、豚鼠和牛身上进行的毒理学评估未发现中毒的临床症状。此外，在猪、羊、仓鼠、大鼠和兔子身上进行的致畸学研究也表明，在所施用的剂量水平下，动物未出现可观察到的影响。
