Suppr超能文献

Methoprene photolytic compounds disrupt zebrafish development, producing phenocopies of mutants in the sonic hedgehog signaling pathway.

作者信息

Smith Denice G, Wilburn Claudia, McCarthy Robert A

机构信息

Department of Biology, Chemistry and Environmental Science, Christopher Newport University, 1 University Place, Newport News, VA 23606, USA.

出版信息

Mar Biotechnol (NY). 2003 Mar-Apr;5(2):201-12. doi: 10.1007/s10126-002-0062-5.

Abstract

Environmental chemicals have been proposed to impact endocrine or retinoid pathways, causing developmental abnormalities in humans and other vertebrates. Presented evidence shows that exposure of zebrafish embryos to sunlight-induced photolytic products of the pesticide methoprene results in developmental defects in the head, heart, pectoral fins, and somites, and in spinal motor and optic nerve axons. Exposed embryos are phenocopies of zebrafish you-type mutants and, as in the mutant sonic-you, show underexpression of the signaling protein sonic hedgehog. Reduced expression of sonic hedgehog is also displayed in embryos treated with the retinoic acid synthesis inhibitor citral. This study identifies citral-related compounds as embryonic signaling disruptors of potential environmental concern.

摘要

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验