生物组织短脉冲激光消融的热弹性基础。
The thermoelastic basis of short pulsed laser ablation of biological tissue.
作者信息
Itzkan I, Albagli D, Dark M L, Perelman L T, von Rosenberg C, Feld M S
机构信息
Laser Biomedical Research Center, George R. Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge 02139.
出版信息
Proc Natl Acad Sci U S A. 1995 Mar 14;92(6):1960-4. doi: 10.1073/pnas.92.6.1960.
Strong evidence that short-pulse laser ablation of biological tissues is a photomechanical process is presented. A full three-dimensional, time-dependent solution to the thermoelastic wave equation is compared to the results of experiments using an interferometric surface monitor to measure thermoelastic expansion. Agreement is excellent for calibrations performed on glass and on acrylic at low laser fluences. For cortical bone, the measurements agree well with the theoretical predictions once optical scattering is included. The theory predicts the presence of the tensile stresses necessary to rupture the tissue during photomechanical ablation. The technique is also used to monitor the ablation event both before and after material is ejected.
有充分证据表明，生物组织的短脉冲激光烧蚀是一个光机械过程。将热弹性波动方程的完整三维、时间相关解与使用干涉表面监测器测量热弹性膨胀的实验结果进行了比较。在低激光能量密度下对玻璃和丙烯酸进行校准时，两者吻合得非常好。对于皮质骨，一旦考虑光散射，测量结果与理论预测吻合良好。该理论预测了光机械烧蚀过程中组织破裂所需的拉应力的存在。该技术还用于监测材料喷射前后的烧蚀事件。
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