Department of Physics and Astronomy, University of Texas at San Antonio, One UTSA Circle, San Antonio, TX 78249, USA; TASC Inc., 4141 Petroleum Road, Ft. Sam Houston, TX 78234-2644, USA.
Comput Biol Med. 2013 Dec;43(12):2278-86. doi: 10.1016/j.compbiomed.2013.09.005. Epub 2013 Sep 21.
Since its invention in the early 1960s, the laser has been used as a tool for surgical, therapeutic, and diagnostic purposes. To achieve maximum effectiveness with the greatest margin of safety it is important to understand the mechanisms of light propagation through tissue and how that light affects living cells. Lasers with novel output characteristics for medical and military applications are too often implemented prior to proper evaluation with respect to tissue optical properties and human safety. Therefore, advances in computational models that describe light propagation and the cellular responses to laser exposure, without the use of animal models, are of considerable interest. Here, a physics-based laser-tissue interaction model was developed to predict the dynamic changes in the spatial and temporal temperature rise during laser exposure to biological tissues. Unlike conventional models, the new approach is grounded on the rigorous electromagnetic theory that accounts for wave interference, polarization, and nonlinearity in propagation using a Maxwell's equations-based technique.
自 20 世纪 60 年代发明以来，激光已被用作手术、治疗和诊断目的的工具。为了在最大的安全裕度下实现最大的效果，了解光在组织中的传播机制以及光如何影响活细胞非常重要。对于医疗和军事应用具有新颖输出特性的激光在适当评估组织光学特性和人体安全性之前通常就已付诸实施。因此，描述光传播和细胞对激光照射反应的计算模型的进展，而无需使用动物模型，具有相当大的意义。在这里，开发了一种基于物理的激光-组织相互作用模型，以预测激光照射生物组织时空间和时间温度升高的动态变化。与传统模型不同，新方法基于严格的电磁理论，该理论使用基于麦克斯韦方程组的技术来考虑传播中的波干扰、偏振和非线性。
