Amarante M T, Constantinescu M A, O'Connor D, Yaremchuk M J
Division of Plastic and Reconstructive Surgery, Massachusetts General Hospital, Harvard Medical School, Boston.
Plast Reconstr Surg. 1995 Apr;95(4):639-46. doi: 10.1097/00006534-199504000-00004.
This study examined the feasibility of achieving bone fixation of the upper facial skeleton using n-butyl-2-cyanoacrylate. We compared the fixation obtained with this adhesive to that obtained with plates and screws in an animal model. The stability of fixation of both osteotomies and onlay grafts was studied in six minipigs. Three osteotomies were performed on each side of the skull. Additionally, a parietal split-thickness autograft was fixated to the nasal bone as an onlay. Plates and screws were used on the right and adhesive on the left. The animals were killed at 6 weeks, and both sides were compared biomechanically and histologically. Clinical assessment showed stability of all fragments. No statistical difference was found in the comparison of the maximum torque to failure between analogous plated and glued sides. Radiographic cephalometry revealed no significant displacement of the fragments. Histologic analysis demonstrated bony union. In this study, n-butyl-2-cyanoacrylate was as effective as plates and screws in the fixation of surgically created osteotomies of the upper facial skeleton.
本研究探讨了使用正丁基-2-氰基丙烯酸酯实现上颌面部骨骼骨固定的可行性。我们在动物模型中将这种粘合剂获得的固定效果与钢板和螺钉获得的固定效果进行了比较。在六只小型猪中研究了截骨术和贴附移植骨固定的稳定性。在颅骨的每一侧进行三次截骨术。此外，将一块顶骨分层自体移植物作为贴附物固定于鼻骨。右侧使用钢板和螺钉，左侧使用粘合剂。动物在6周时处死，对两侧进行生物力学和组织学比较。临床评估显示所有骨块均稳定。在类似的钢板固定侧和粘合剂固定侧之间，比较最大破坏扭矩时未发现统计学差异。头颅X线测量显示骨块无明显移位。组织学分析显示有骨愈合。在本研究中，正丁基-2-氰基丙烯酸酯在上颌面部骨骼手术造成的截骨术固定方面与钢板和螺钉一样有效。
