Podos S M
Invest Ophthalmol. 1976 Oct;15(10):851-4.
The ionophores A23187 and X537A, which increase the permeability of cell membranes to calcium and other divalent cations, produced significant elevation of intraocular pressure in rabbits. Topical instillation of these ionophores in concentrations of 1.0 and 0.1 per cent were effective. Aqueous humor protein and facility of outflow were similar in ionophore-treated and control eyes. Pretreatment with indomethacin did not block the intraocular pressure rise induced by A23187. Alterations of intracellular calcium might control cellular processes within the eye as in many other biological systems.
离子载体A23187和X537A可增加细胞膜对钙和其他二价阳离子的通透性，它们可使兔眼压显著升高。以1.0%和0.1%的浓度局部滴注这些离子载体是有效的。经离子载体处理的眼睛和对照眼的房水蛋白及房水流畅系数相似。用吲哚美辛预处理不能阻止A23187引起的眼压升高。细胞内钙的变化可能像在许多其他生物系统中一样控制眼内的细胞过程。
