van Hilten J J, Hoff J I, Middelkoop H A, Roos R A
Department of Neurology, Academic Hospital, Leiden, The Netherlands.
J Neural Transm Park Dis Dement Sect. 1994;8(1-2):117-21. doi: 10.1007/BF02250922.
In this study we evaluate the feasibility of measures that reflect different characteristics of motor activity and immobility in the objective quantification of hypokinesia. Because by definition hypokinesia can only be assessed over a period of time, continuous activity monitoring was used during 5 successive days in the home setting in 64 patients with Parkinson's disease (PD) and 104 healthy elderly subjects. In the patients we also evaluated the relation between the monitor measures and subjective measures of hypokinesia and age. Compared to the healthy elderly subjects, PD patients have a decreased activity level, increased proportion of time without movement, elevated mean duration of immobility, and decreased percentage of short-lasting immobility periods. Differences between both groups were most prominent for those measures that incorporate or reflect immobility. Moreover, in the PD patients the mean duration of immobility and percentage of short-lasting immobility periods show an apparent lack of relation with age and clinical ratings obtained from the UPDRS. In conclusion, our findings underscore the poor representation of hypokinesia in the UPDRS and value of objective quantification of this fundamental impairment of PD.
在本研究中，我们评估了反映运动活动和静止不同特征的指标在客观量化运动迟缓方面的可行性。由于根据定义，运动迟缓只能在一段时间内进行评估，因此我们在64例帕金森病（PD）患者和104名健康老年受试者的家中连续5天使用了连续活动监测。在患者中，我们还评估了监测指标与运动迟缓主观指标和年龄之间的关系。与健康老年受试者相比，PD患者的活动水平降低，无运动时间比例增加，静止平均持续时间延长，短暂静止期百分比降低。两组之间的差异在那些包含或反映静止的指标上最为显著。此外，在PD患者中，静止平均持续时间和短暂静止期百分比与年龄以及从统一帕金森病评定量表（UPDRS）获得的临床评分明显缺乏相关性。总之，我们的研究结果强调了UPDRS中运动迟缓表现不佳，以及对PD这种基本损害进行客观量化的价值。
