Dunnewold R J, Hoff J I, van Pelt H C, Fredrikze P Q, Wagemans E A, van Hilten B J
Department of Neurology, Leiden University Medical Centre, The Netherlands.
J Clin Neurophysiol. 1998 May;15(3):235-42. doi: 10.1097/00004691-199805000-00007.
We used ambulatory monitoring to quantify body position, bradykinesia, and hypokinesia simultaneously in 50 patients with Parkinson's disease (PD) and 43 healthy elderly during the diurnal period. Reliable automatic detection of three defined body positions proved possible. As compared with controls, PD patients spent less time upright and more time during the day lying down, which correlated well with the self-reported time spent lying down. PD patients had significantly lower mean values of extremity acceleration and higher mean values of immobility than controls. The objective measures of bradykinesia and hypokinesia showed only a modest or no relation to the semiquantitative subjective Unified Parkinson's Disease Rating Scale (UPDRS) motor scores, which most likely was due to differences between the methods. In contrast to bradykinesia measures, hypokinesia measures showed clear sex differences in both patients and controls. Over time, trunk and arm movements occurred more frequently in women than in men. Our ambulatory monitoring assessment disclosed clinically relevant information about the mobility profile and offers a way to quantify cardinal movement features simultaneously in PD patients throughout the day.
我们采用动态监测技术，在日间时段同时对50例帕金森病（PD）患者和43名健康老年人的身体姿势、运动迟缓及运动减少情况进行量化评估。结果表明，能够可靠地自动检测出三种明确的身体姿势。与对照组相比，PD患者日间直立时间减少，躺卧时间增多，且这一结果与患者自我报告的躺卧时间密切相关。PD患者肢体加速度的平均值显著低于对照组，而静止不动的平均值则高于对照组。运动迟缓与运动减少的客观测量结果与半定量主观统一帕金森病评定量表（UPDRS）运动评分之间仅存在适度关联或无关联，这很可能是由于测量方法的差异所致。与运动迟缓测量结果不同，运动减少测量结果在患者和对照组中均显示出明显的性别差异。随着时间推移，女性躯干和手臂运动的发生频率高于男性。我们的动态监测评估揭示了有关运动特征的临床相关信息，并提供了一种在一天中同时量化PD患者主要运动特征的方法。
