Cameron H U
J Biomed Mater Res. 1976 Sep;10(5):769-76. doi: 10.1002/jbm.820100509.
In order to establish a base line for tissue reaction in relationship to loaded implanted foreign materials that might be used for comparison with new materials, the interface between the trabecular bone in the femoral head and hip nails has been studied in 20 specimens. The interface consists of four distinguishable layers: a cellular layer at the surface, a layer of fibrovascular connective tissue, a layer of collagenous connective tissue and/or fibrocartilage, and a peri-implant bone plate. Even 10 years after insertion of the nail this interface remained cellularly active, the activity presumably being related to the different modulus of elasticity between the metal and the surrounding trabecular bone.
为了建立与可能用于与新材料比较的负载植入异物相关的组织反应基线，对20个标本中股骨头小梁骨与髋钉之间的界面进行了研究。该界面由四个可区分的层组成：表面的细胞层、纤维血管结缔组织层、胶原结缔组织和/或纤维软骨层以及植入物周围骨板。即使在钉子插入10年后，该界面仍保持细胞活性，这种活性可能与金属和周围小梁骨之间不同的弹性模量有关。
