心房利钠肽抑制了精氨酸血管加压素对蟾蜍皮肤的促钠排泄和水渗透作用。

Atrial natriuretic peptide inhibited the natriferic and hydrosmotic effects of arginine vasotocin on toad skin.

作者信息

Berman D M, Soria M O, Proto de Grifasi M, Coviello A

机构信息

Departamento de Fisiología, INSIBIO, San Miguel de Tucumán, Argentina.

出版信息

Comp Biochem Physiol C Pharmacol Toxicol Endocrinol. 1994 Nov;109(3):277-82.

PMID:7894890

Abstract

The effect of rat atrial natriuretic peptide (rANP) on hormonal stimulated osmotic water permeability (Jw, hydrosmotic effect) and net ion transport (short-circuit current, SCC, natriferic effect) was studied on toad skin, a tissue with functional similarities to the mammalian distal nephron, in order to assess actions on transport mechanisms. Rat atrial natriuretic peptide, rANP-99-126 (rANP) inhibited stimulated SCC and Jw to submaximal concentrations of arginine vasotocin (AVT) at a site before cyclic AMP generation. The angiotensin-converting enzyme inhibitor (ACEI) MK-422 did not modify the inhibitory effect of ANP in the stimulated Jw.

摘要

为了评估对转运机制的作用，研究了大鼠心房利钠肽（rANP）对蟾蜍皮肤（一种在功能上与哺乳动物远端肾单位相似的组织）激素刺激的渗透水通透性（Jw，渗透效应）和净离子转运（短路电流，SCC，排钠效应）的影响。大鼠心房利钠肽rANP - 99 - 126（rANP）在环磷酸腺苷生成之前的位点，将刺激的SCC和Jw抑制至精氨酸加压素（AVT）的亚最大浓度。血管紧张素转换酶抑制剂（ACEI）MK - 422并未改变ANP对刺激的Jw的抑制作用。