Matsuda H, Uesugi H, Kamata K, Sunohara N, Yagishita A
Department of Radiology and Nuclear Medicine, National Center of Neurology and Psychiatry, Tokyo, Japan.
Clin Nucl Med. 1995 Jan;20(1):52-4. doi: 10.1097/00003072-199501000-00013.
Regional cerebral blood flow (rCBF) measurement using Tc-99m HMPAO angiography and SPECT was performed in a patient with adrenoleukodystrophy. The whole brain CBF showed great reduction to 31 ml/100 g/min as compared with an age-matched normal value of 45.9 ml/100 g/min. rCBF showed extremely decreased values of approximately 28 and 10 ml/100 g/min in bilateral frontal cortex and white matter respectively. The SPECT scan provided useful information on gray matter involvement to MRI findings of widespread white matter lesions. This quantitative nuclear medicine technique may contribute to pathophysiologic evaluation of adrenoleukodystrophy complementary with MRI.
使用锝-99m六甲基丙二胺肟血管造影术和单光子发射计算机断层扫描（SPECT）对一名肾上腺脑白质营养不良患者进行了局部脑血流量（rCBF）测量。与年龄匹配的正常数值45.9 ml/100 g/min相比，全脑脑血流量大幅降低至31 ml/100 g/min。双侧额叶皮质和白质的rCBF分别极低，约为28和10 ml/100 g/min。SPECT扫描为广泛白质病变的MRI结果提供了有关灰质受累情况的有用信息。这种定量核医学技术可能有助于对肾上腺脑白质营养不良进行病理生理学评估，作为MRI的补充手段。
