Hiltunen M, Hyöty H, Leinikki P, Akerblom H K, Tuomilehto J, Vesikari T
Department of Biomedical Sciences, University of Tampere, Finland.
Diabet Med. 1994 Dec;11(10):942-6. doi: 10.1111/j.1464-5491.1994.tb00251.x.
Mumps-measles-rubella vaccination-induced antibody responses were studied in Type 1 diabetic children to find out the possible aberrations in mumps antibody responsiveness previously seen after natural mumps in Type 1 diabetic children. Mumps, measles, and rubella virus antibodies were studied in 364 newly diagnosed Type 1 diabetic subjects, their 240 non-diabetic siblings and 59 age- and sex-matched, unrelated, non-diabetic control subjects who all had received mumps-measles-rubella vaccine but had not had the respective infections. Sera were collected from all children at the time of the diagnosis of diabetes in the index case which was on average 2.5 years after the mumps-measles-rubella vaccination. The levels of IgG class mumps virus antibodies were lower in diabetic patients than in their non-diabetic siblings (p < 0.0005). This difference was most pronounced in males as male patients had significantly lower IgG mumps antibody levels than female patients. Rubella and measles IgG antibodies did not differ between patients and control subjects. The results are in accordance with previous studies suggesting a selective decrease in mumps antibody levels in Type 1 diabetic children. As the exposure to mumps virus had been exactly the same in all study groups, low mumps antibodies in diabetic children suggest decreased responsiveness rather than different number of past infections in these patients.
在1型糖尿病儿童中研究了腮腺炎-麻疹-风疹疫苗诱导的抗体反应，以找出先前在1型糖尿病儿童自然感染腮腺炎后观察到的腮腺炎抗体反应可能存在的异常。在364名新诊断的1型糖尿病受试者、他们的240名非糖尿病兄弟姐妹以及59名年龄和性别匹配、无亲缘关系的非糖尿病对照受试者中研究了腮腺炎、麻疹和风疹病毒抗体，这些受试者均接种了腮腺炎-麻疹-风疹疫苗，但未发生相应感染。在索引病例诊断糖尿病时从所有儿童中采集血清，此时平均在接种腮腺炎-麻疹-风疹疫苗后2.5年。糖尿病患者中IgG类腮腺炎病毒抗体水平低于其非糖尿病兄弟姐妹（p<0.0005）。这种差异在男性中最为明显，因为男性患者的IgG腮腺炎抗体水平显著低于女性患者。患者和对照受试者之间的风疹和麻疹IgG抗体没有差异。结果与先前的研究一致，表明1型糖尿病儿童的腮腺炎抗体水平有选择性下降。由于所有研究组接触腮腺炎病毒的情况完全相同，糖尿病儿童中低水平的腮腺炎抗体表明这些患者的反应性降低，而不是既往感染次数不同。
