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血管活性肠肽及其同源物对去甲肾上腺素介导的大鼠下颌下腺液体和蛋白质分泌的影响。

Effects of vasoactive intestinal peptide and its homologues on the noradrenaline-mediated secretion of fluid and protein from the rat submandibular gland.

作者信息

Iwabuchi Y, Masuhara T

机构信息

Department of Dental Pharmacology, School of Dentistry at Niigata, Nippon Dental University, Japan.

出版信息

Gen Pharmacol. 1994 Nov;25(7):1427-34. doi: 10.1016/0306-3623(94)90169-4.

DOI:10.1016/0306-3623(94)90169-4
PMID:7896056
Abstract
  1. Noradrenaline-mediated secretion of fluid and protein from rat submandibular glands was enhanced by vasoactive intestinal peptide (VIP) and secretin but not by peptide histidine isoleucine (PHI) or gastric inhibitory peptide (GIP). 2. The synergistic effect of the combination of VIP with noradrenaline (NA) was antagonized by pretreatment with prazosin or phentolamine but not by pretreatment with yohimbine or propranolol. 3. These results suggest that VIP and secretin but not PHI and GIP can significantly enhance the secretion of fluid and protein that is mediated by NA in rat submandibular gland and that the synergistic effect of VIP and NA involves both alpha 1-adrenergic receptors and receptors for VIP.
摘要
  1. 血管活性肠肽（VIP）和促胰液素可增强去甲肾上腺素介导的大鼠下颌下腺液体和蛋白质分泌，但肽组氨酸异亮氨酸（PHI）或胃抑制肽（GIP）则无此作用。2. 用哌唑嗪或酚妥拉明预处理可拮抗VIP与去甲肾上腺素（NA）联合的协同作用，而用育亨宾或普萘洛尔预处理则无此作用。3. 这些结果表明，VIP和促胰液素而非PHI和GIP可显著增强去甲肾上腺素介导的大鼠下颌下腺液体和蛋白质分泌，且VIP与NA的协同作用涉及α1 - 肾上腺素能受体和VIP受体。

相似文献

1
Effects of vasoactive intestinal peptide and its homologues on the noradrenaline-mediated secretion of fluid and protein from the rat submandibular gland.血管活性肠肽及其同源物对去甲肾上腺素介导的大鼠下颌下腺液体和蛋白质分泌的影响。
Gen Pharmacol. 1994 Nov;25(7):1427-34. doi: 10.1016/0306-3623(94)90169-4.
2
Effects of vasoactive intestinal peptide and its homologues on the acetylcholine-mediated secretion of fluid and protein from the rat submandibular gland.血管活性肠肽及其同源物对大鼠下颌下腺乙酰胆碱介导的液体和蛋白质分泌的影响。
Gen Pharmacol. 1995 Sep;26(5):961-70. doi: 10.1016/0306-3623(94)00298-2.
3
Effects of vasoactive intestinal peptide and its homologues on the substance P-mediated secretion of fluid and protein from the rat submandibular gland.血管活性肠肽及其同源物对P物质介导的大鼠下颌下腺液体和蛋白质分泌的影响。
Gen Pharmacol. 1994 Jul;25(4):705-11. doi: 10.1016/0306-3623(94)90249-6.
4
Elevation of intracellular cAMP by noradrenaline and vasoactive intestinal peptide in striated ducts isolated from the rabbit mandibular salivary gland.去甲肾上腺素和血管活性肠肽对兔下颌下腺纹状管细胞内cAMP水平的升高作用
Arch Oral Biol. 1996 Jul;41(7):689-94. doi: 10.1016/s0003-9969(96)00028-3.
5
Interaction of peptides related to VIP and secretin with guinea pig pancreatic acini.与血管活性肠肽（VIP）和促胰液素相关的肽与豚鼠胰腺腺泡的相互作用。
Am J Physiol. 1989 Feb;256(2 Pt 1):G283-90. doi: 10.1152/ajpgi.1989.256.2.G283.
6
Effects of acute and long-term atropine treatment on levels, release and response to VIP and PHI in the submandibular gland of cat and rat.急性和长期阿托品治疗对猫和大鼠下颌下腺中血管活性肠肽（VIP）和胰高血糖素样肽（PHI）水平、释放及反应的影响。
Acta Physiol Scand. 1992 Nov;146(3):357-67. doi: 10.1111/j.1748-1716.1992.tb09430.x.
7
Expression of vasoactive intestinal polypeptide receptor mRNA and secretory regulation by vasoactive intestinal polypeptide in rat submandibular and sublingual salivary glands.大鼠颌下腺和舌下腺中血管活性肠肽受体mRNA的表达及血管活性肠肽的分泌调节
Arch Oral Biol. 1997 Mar;42(3):197-204. doi: 10.1016/S0003-9969(97)00002-2.
8
Assessment of the effects of vasoactive intestinal peptide (VIP) on blood flow through and salivation of the dog salivary gland in comparison with those of secretin, glucagon and acetylcholine.比较血管活性肠肽（VIP）与促胰液素、胰高血糖素和乙酰胆碱对犬唾液腺血流和唾液分泌的影响。
Br J Pharmacol. 1979 Apr;65(4):683-7. doi: 10.1111/j.1476-5381.1979.tb07882.x.
9
Effects of VIP, PHM and substance P on blood vessels and secretory elements of the human submandibular gland.血管活性肠肽、胰高血糖素样肽和P物质对人下颌下腺血管及分泌成分的影响。
Regul Pept. 1986 Feb;13(3-4):319-26. doi: 10.1016/0167-0115(86)90049-2.
10
Preoptic injection of VIP, but not of secretin or PHI, inhibits LH and stimulates prolactin secretion in the ovariectomized rat.在去卵巢大鼠中，视前区注射血管活性肠肽（VIP）可抑制促黄体生成素（LH）并刺激催乳素分泌，而注射促胰液素或肽组氨酸异亮氨酸（PHI）则无此作用。
Brain Res. 1988 Feb 16;441(1-2):367-70. doi: 10.1016/0006-8993(88)91416-3.

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