比较血管活性肠肽（VIP）与促胰液素、胰高血糖素和乙酰胆碱对犬唾液腺血流和唾液分泌的影响。
Assessment of the effects of vasoactive intestinal peptide (VIP) on blood flow through and salivation of the dog salivary gland in comparison with those of secretin, glucagon and acetylcholine.
作者信息
Shimizu T, Taira N
出版信息
Br J Pharmacol. 1979 Apr;65(4):683-7. doi: 10.1111/j.1476-5381.1979.tb07882.x.
Abstract
- The vascular bed of the submandibular gland in situ was perfused with blood through the glandular artery at a constant pressure in anesthetized dogs. All drugs were administered intra-arterially. 2. Vasoactive intestinal peptide (VIP), secretin and acetylcholine produced a dose-dependent increase in blood flow through the artery (vasodilatation) but glucagon was almost ineffective. 3. Dose-blood flow response curves for VIP and secretin were parallel, and VIP was about 100 times as potent as secretin on a molar basis. Dose-blood flow response curves for acetylcholine were flatter than those for VIP and secretin. Acetylcholine was approximately as potent as secretin on a molar basis. 4. No tachyphylaxis developed to the vasodilator action of VIP. 5. The vasodilator responses to VIP and to electrical stimulation of the chordolingual nerve were scarcely modified by (-)-hyoscyamine in doses that fully antagonized the vasodilator response to acetylcholine. 6. VIP, secretin and glucagon were ineffective in eliciting salivary secretion. 7. The possibility that VIP is released from parasympathetic vasodilator nerves and mediates the atropine-resistant vasodilatation in the dog submandibular gland is discussed.
摘要
- 在麻醉犬中，通过腺动脉以恒定压力向原位下颌下腺的血管床灌注血液。所有药物均经动脉给药。2. 血管活性肠肽（VIP）、促胰液素和乙酰胆碱使通过动脉的血流量呈剂量依赖性增加（血管舒张），但胰高血糖素几乎无效。3. VIP和促胰液素的剂量 - 血流反应曲线平行，按摩尔计算，VIP的效力约为促胰液素的100倍。乙酰胆碱的剂量 - 血流反应曲线比VIP和促胰液素的更平缓。按摩尔计算，乙酰胆碱的效力与促胰液素大致相同。4. 对VIP的血管舒张作用未产生快速耐受性。5. 剂量足以完全拮抗乙酰胆碱血管舒张反应的（-）-莨菪碱几乎不改变对VIP和舌神经电刺激的血管舒张反应。6. VIP、促胰液素和胰高血糖素在引发唾液分泌方面无效。7. 讨论了VIP从副交感神经血管舒张神经释放并介导犬下颌下腺中阿托品抵抗性血管舒张的可能性。
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本文引用的文献
1
Reactions of denervated voluntary muscle, and their bearing on the mode of action of parasympathetic and related nerves.失神经支配的随意肌反应及其与副交感神经及相关神经作用方式的关系。
J Physiol. 1930 Sep 18;70(2):109-44. doi: 10.1113/jphysiol.1930.sp002682.
2
Efferent and antidromic vasodilator impulses to the tongue in the chorda-lingual nerve of the cat.猫的鼓索 - 舌神经中至舌部的传出性及逆行性血管舒张冲动。
Acta Physiol Scand. 1952;25(1):10-4. doi: 10.1111/j.1748-1716.1952.tb00854.x.
3
Vasodilatation in the tongue and its relationship to plasma kinin formation.舌部血管舒张及其与血浆激肽形成的关系。
J Physiol. 1958 Dec 30;144(3):532-40. doi: 10.1113/jphysiol.1958.sp006118.
4
The mechanism of the functional hyperaemia in the submandibular salivary gland.下颌下唾液腺功能性充血的机制。
J Physiol. 1955 Aug 29;129(2):253-71. doi: 10.1113/jphysiol.1955.sp005351.
5
Polypeptide with broad biological activity: isolation from small intestine.具有广泛生物活性的多肽：从小肠中分离得到。
Science. 1970 Sep 18;169(3951):1217-8. doi: 10.1126/science.169.3951.1217.
6
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Eur J Biochem. 1972 Jul 13;28(2):199-204. doi: 10.1111/j.1432-1033.1972.tb01903.x.
7
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Eur J Biochem. 1974 Mar 1;42(2):581-9. doi: 10.1111/j.1432-1033.1974.tb03373.x.
8
Cellular localization of a vasoactive intestinal peptide in the mammalian and avian gastrointestinal tract.血管活性肠肽在哺乳动物和鸟类胃肠道中的细胞定位。
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9
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Tohoku J Exp Med. 1972 Dec;108(4):377-88. doi: 10.1620/tjem.108.377.
10
Vasoactive intestinal polypeptide: abundant immunoreactivity in neural cell lines and normal nervous tissue.血管活性肠肽：在神经细胞系和正常神经组织中具有丰富的免疫反应性。
Science. 1976 May 28;192(4242):907-8. doi: 10.1126/science.1273576.
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