在完全H-2不相容的嵌合体中，供体来源的T细胞可对与供体或宿主H-2类型相关的次要组织相容性抗原产生反应。
In a fully H-2 incompatible chimera, T cells of donor origin can respond to minor histocompatibility antigens in association with either donor or host H-2 type.
作者信息
Matzinger P, Mirkwood G
出版信息
J Exp Med. 1978 Jul 1;148(1):84-92. doi: 10.1084/jem.148.1.84.
Abstract
Fully H-2 incompatible radiation chimeras were prepared using BALB congenic mice. Such chimeric mice were immunized in vivo against histocompatibility antigens of the C57BL/10Sn (B10) background in association with either of the parental H-2 haplotypes, and their spleen cells subsequently boosted in vitro with the same minor antigens. Strong H-2-restricted cytotoxic activity against minor antigens was detected, and the specificity of the restriction could be to the H-2 haplotype of the donor or the host depending on the cells used for priming or boosting. Cross priming could also be demonstrated in these mice. The results show that fully allogenic radiation chimeras can produce H-2-restricted T-cell responses to minor histocompatibility (H) antigens, and are discussed in relation to contrasting results recently obtained against viral antigens.
摘要
使用BALB同源近交系小鼠制备完全H-2不相容的辐射嵌合体。将此类嵌合小鼠在体内针对C57BL/10Sn（B10）背景的组织相容性抗原与任一亲本H-2单倍型联合进行免疫，随后用相同的次要抗原在体外增强其脾细胞。检测到针对次要抗原的强H-2限制性细胞毒性活性，并且根据用于初次免疫或增强免疫的细胞，限制性的特异性可以是供体或宿主的H-2单倍型。在这些小鼠中也可以证明交叉致敏。结果表明，完全同种异体辐射嵌合体可以产生针对次要组织相容性（H）抗原的H-2限制性T细胞反应，并结合最近针对病毒抗原获得的对比结果进行了讨论。
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In a fully H-2 incompatible chimera, T cells of donor origin can respond to minor histocompatibility antigens in association with either donor or host H-2 type.在完全H-2不相容的嵌合体中，供体来源的T细胞可对与供体或宿主H-2类型相关的次要组织相容性抗原产生反应。
J Exp Med. 1978 Jul 1;148(1):84-92. doi: 10.1084/jem.148.1.84.
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