Cunnigham R K, Thacore H R, Zhou P, Terzian R, Nakeeb S, Zaleski M B
Department of Microbiology, State University of New York at Buffalo 14214.
Immunol Res. 1994;13(1):21-8. doi: 10.1007/BF02918221.
The LP-BM5 mixture of murine retroviruses elicits a disease in mice referred to as murine immunodeficiency syndrome (MAIDS) that is considered by some to be an animal homologue of human AIDS. In this article, we present and discuss some recent findings on the pathogenesis of the murine disease and their implications for the proposed homology between murine and human syndromes. The murine disease seems to display as many similarities to as it does differences from human AIDS. Among the latter are: definitive and exclusive viral etiology, a strong genetic effect on susceptibility to infection, expansion of the CD4+ cell population in spleen and peripheral blood, consistent transmissibility by a single transfusion of the minute amounts of blood or plasma from infected donors, and striking similarity between virus-induced alteration of the in vitro spleen cell proliferation and those caused by treatment with a protein kinase inhibitor K252a. With this in mind, the use of the noncommittal term retrovirus-induced murine lymphoproliferative disease instead of MAIDS appears to be more appropriate at this time.
鼠逆转录病毒的LP - BM5混合物在小鼠中引发一种被称为鼠免疫缺陷综合征（MAIDS）的疾病，一些人认为它是人类艾滋病的动物同源物。在本文中，我们展示并讨论了关于这种鼠类疾病发病机制的一些最新发现，以及它们对所提出的鼠类和人类综合征之间同源性的影响。这种鼠类疾病与人类艾滋病似乎既有许多相似之处，也有不同之处。后者包括：明确且唯一的病毒病因、对感染易感性有很强的遗传效应、脾脏和外周血中CD4 +细胞群体的扩增、通过单次输注来自受感染供体的微量血液或血浆具有一致的传染性，以及病毒诱导的体外脾细胞增殖改变与用蛋白激酶抑制剂K252a处理所引起的改变之间存在显著相似性。考虑到这一点，此时使用不明确的术语逆转录病毒诱导的鼠类淋巴细胞增生性疾病而非MAIDS似乎更为合适。
