Briem H, Safary A
Department of Infectious Diseases, Reykjavik City Hospital, Iceland.
J Med Virol. 1994 Dec;44(4):443-5. doi: 10.1002/jmv.1890440424.
An inactivated vaccine against hepatitis A was administered as a single 1,440 enzyme-linked immunosorbent assay (ELISA) units dose at month 0 with a booster at month 6 to 200 subjects divided into two age groups: group 1, 20-39 years (n = 134) and group II, 40-62 years (n = 66). At day 15, the seropositivity rates were 90% and 77% in groups I and II, respectively. At month 1 the seropositivity rate was 97% in both groups. At month 6 the seropositivity rates were 94% and 88% in groups I and II, respectively. One month after the booster, at month 7, 100% in both groups had become seropositive. The vaccine was well tolerated and did not cause any severe reactions. The results indicate that a single high vaccine dose offers protection against hepatitis A virus (HAV) for at least 6 months in the majority of cases where rapid vaccination is required even in travellers of older age. A booster dose will ensure long-term protection.
一种甲型肝炎灭活疫苗在第0个月以单剂量1440酶联免疫吸附测定（ELISA）单位接种给200名受试者，分为两个年龄组：第1组，20 - 39岁（n = 134）；第II组，40 - 62岁（n = 66），并在第6个月进行加强免疫。在第15天，第I组和第II组的血清阳性率分别为90%和77%。在第1个月，两组的血清阳性率均为97%。在第6个月，第I组和第II组的血清阳性率分别为94%和88%。在加强免疫后1个月，即第7个月，两组的血清阳性率均达到100%。该疫苗耐受性良好，未引起任何严重反应。结果表明，在大多数需要快速接种疫苗的情况下，即使是老年旅行者，单剂量高疫苗接种至少6个月可提供针对甲型肝炎病毒（HAV）的保护。加强剂量将确保长期保护。
