Zhao Yueyuan, Jin Hui, Zhang Xuefeng, Wang Bei, Liu Pei
a School of Public Health, Southeast University , Nanjing , China.
b Key Laboratory of Environmental Medicine Engineering, Ministry of Education , Nanjing , China.
Hum Vaccin Immunother. 2016 Apr 2;12(4):894-902. doi: 10.1080/21645515.2015.1132129.
Viral hepatitis is a serious global public health problem. It is also a common cause of jaundice and gestational complications in pregnant women. Moreover, infected mothers can transmit the virus to their fetus or neonate, which may increase disease burden and decrease quality of life. To date, commercial vaccines have been developed for hepatitis A, B, and E and are available to the general population. The Advisory Committee on Immunization Practices currently accepts emergency vaccination against hepatitis A and B during pregnancy due to benefits that overweight the potential risks. While there are limited data from trials with limited numbers of samples that suggest the efficacy or safety of hepatitis B and E vaccines in pregnant women, additional data are necessary to provide evidence of vaccination during pregnancy.
病毒性肝炎是一个严重的全球公共卫生问题。它也是孕妇黄疸和妊娠并发症的常见原因。此外，受感染的母亲可将病毒传播给胎儿或新生儿，这可能会增加疾病负担并降低生活质量。迄今为止，已经开发出甲型、乙型和戊型肝炎的商用疫苗，可供普通人群使用。免疫实践咨询委员会目前认可在孕期进行甲型和乙型肝炎的紧急接种，因为其益处大于潜在风险。虽然样本数量有限的试验数据表明乙型和戊型肝炎疫苗在孕妇中的有效性或安全性，但仍需要更多数据来证明孕期接种疫苗的证据。
