Mafune K, Takubo K, Tanaka Y, Fujita K
Department of Surgery, Saitama Cancer Center Hospital, Japan.
J Surg Oncol. 1995 Mar;58(3):184-90. doi: 10.1002/jso.2930580309.
Mucoepidermoid carcinoma of the esophagus is a particularly rare lesion, and only 24 cases have been reported in the English literature. Using histochemical methods, we identified four (3.1%) of 135 resected primary esophageal cancers as mucoepidermoid carcinomas. Gross examination of these four tumors disclosed sclerosing submucosal infiltration with shallow surface ulceration, which had appeared as a funnel-shaped constriction on esophagram. The intraepithelial spread of the tumor in two cases and the close relationship between foci of invading carcinoma and regions of dysplastic epithelium in the remaining two cases suggest that esophageal mucoepidermoid carcinoma may originate in the squamous epithelium. Although mucoepidermoid carcinoma should theoretically offer a fair prognosis, the outcome for patients with this lesion has generally been as poor as patients with typical squamous cell carcinoma. This further implies that mucoepidermoid carcinomas may arise from the squamous epithelium.
食管黏液表皮样癌是一种极为罕见的病变，英文文献中仅报道过24例。通过组织化学方法，我们在135例切除的原发性食管癌中识别出4例（3.1%）为黏液表皮样癌。对这4例肿瘤的大体检查发现为硬化性黏膜下浸润伴浅表性表面溃疡，在食管造影上表现为漏斗状狭窄。2例肿瘤的上皮内播散以及其余2例侵袭性癌灶与发育异常上皮区域之间的密切关系提示，食管黏液表皮样癌可能起源于鳞状上皮。尽管理论上黏液表皮样癌预后可能较好，但该病变患者的结局通常与典型鳞状细胞癌患者一样差。这进一步表明黏液表皮样癌可能起源于鳞状上皮。
