Azuine M A, Bhide S V
Division of Pharmaceutical Microbiology and Biotechnology, National Institute for Pharmaceutical Research and Development, Abuja, Nigeria.
J Ethnopharmacol. 1994 Dec;44(3):211-7. doi: 10.1016/0378-8741(94)01188-5.
Catechin and dietary turmeric (Curcuma longa) were used as chemopreventive agents in benzo[a]pyrene induced forestomach tumors in Swiss mice and methyl-(acetoxymethyl)-nitrosamine induced oral mucosal tumors in Syrian golden hamsters. Catechin in drinking water and dietary turmeric significantly inhibited the tumor burden and tumor incidence in both tumor models. The induction of oral tumors in golden hamsters was delayed by catechin and dietary turmeric. Adjuvant chemoprevention utilising both catechin and dietary turmeric inhibited both the gross tumor yield and burden more effectively than when compared to individual components in both tumor models. A single i.p. injection of catechin to male Swiss mice induced increased forestomach and hepatic glutathione S-transferase (GST) activity when compared to controls. These findings suggest that catechin and turmeric which are regularly consumed natural products, are effective in mice or golden hamsters as chemopreventive agents.
儿茶素和食用姜黄（姜黄属植物）被用作化学预防剂，用于瑞士小鼠中苯并[a]芘诱导的前胃肿瘤以及叙利亚金黄地鼠中甲基（乙酰氧基甲基）亚硝胺诱导的口腔黏膜肿瘤。饮用水中的儿茶素和食用姜黄在两种肿瘤模型中均显著抑制了肿瘤负荷和肿瘤发生率。儿茶素和食用姜黄使金黄地鼠口腔肿瘤的诱导延迟。在两种肿瘤模型中，与单独使用儿茶素或食用姜黄相比，联合使用儿茶素和食用姜黄作为辅助化学预防更有效地抑制了肿瘤的总产率和负担。与对照组相比，对雄性瑞士小鼠单次腹腔注射儿茶素可诱导前胃和肝脏谷胱甘肽S-转移酶（GST）活性增加。这些发现表明，儿茶素和姜黄作为经常食用的天然产物，在小鼠或金黄地鼠中作为化学预防剂是有效的。
