Gabel J C, Dhother S, Drake R E
Department of Anesthesiology, University of Texas-Houston Medical School Houston.
Lymphology. 1994 Dec;27(4):189-92.
We tested the hypothesis that increased lymph flow from the abdominal organs would increase the pressure within the thoracic duct at the thoracic duct-lung lymphatic junction. Cannulas were placed into the thoracic duct via the caudal mediastinal (lung) node efferent lymphatics in 4 sheep. After the sheep recovered from the surgery, we monitored the thoracic duct pressure with pressure transducers. To increase lymph flow from the lower body, we infused Ringers solution (59 +/- 19 [mean +/- SD] ml/kg body weight in 30 min.) intravenously into the sheep and we inflated a balloon in the inferior vena cava. This technique causes substantial increases in lymph flow from the lower body (mainly from the liver and intestines) through the thoracic duct. During the infusions, the thoracic duct pressure increased significantly from 4.1 +/- 2.9 cm H2O (baseline) to 6.8 +/- 1.7 cm H2O. The neck vein pressure (pressure at the outflow of the thoracic duct) did not increase from baseline (3.0 +/- 2.6 cm H2O). Thus our results support the hypotheses that increased flow through the thoracic duct causes increased thoracic duct pressure.
来自腹部器官的淋巴液流量增加会使胸导管-肺淋巴交接处的胸导管内压力升高。在4只绵羊中，通过尾侧纵隔（肺）淋巴结的传出淋巴管将套管置入胸导管。绵羊术后恢复后，我们用压力传感器监测胸导管压力。为了增加来自下半身的淋巴液流量，我们向绵羊静脉内输注林格氏液（30分钟内输注59±19[平均值±标准差]毫升/千克体重），并在下腔静脉内充入一个气球。该技术使通过胸导管的来自下半身（主要是肝脏和肠道）的淋巴液流量大幅增加。在输注过程中，胸导管压力从4.1±2.9厘米水柱（基线）显著增加至6.8±1.7厘米水柱。颈静脉压力（胸导管流出端的压力）未从基线水平（3.0±2.6厘米水柱）升高。因此，我们的结果支持这样的假设：通过胸导管的流量增加会导致胸导管压力升高。
