Drake R E, Gabel J C
Center for Microvascular and Lymphatic Studies, University of Texas Medical School, Houston.
Lymphology. 1991 Jun;24(2):77-81.
Lymphatic vessels are important in draining excess fluid from the abdominal space and preventing ascites. In sheep, diaphragmatic lymph vessels draining the abdominal space run to the caudal mediastinal lymph node and efferent vessels from the node drain into veins in the neck. To estimate the lymph flow response to excess intraperitoneal fluid in sheep, we cannulated a caudal mediastinal node efferent lymphatic in 5 sheep. After the sheep recovered from the surgery, the lymph flow (QL) was 154 +/- 161 (SD) microliters/min and the lymph protein concentration (CL) was 3.7 +/- 9 g/dl. Lymph flow decreased linearly with increases in lymphatic outflow pressure greater than 6 cmH2O. From this linear QL vs. outflow pressure relationship, we estimated the effective pressure driving lymph flow as the outflow pressure at which QL = 0. At baseline, the driving pressure was 24.7 +/- 14.0 cmH2O. After we infused Ringers solution (10% body weight) into the abdominal space, QL increased significantly to 7.0 +/- 4.1 times baseline and CL decreased significantly to 0.7 +/- 0.6 g/dl. Although the abdominal pressure increased significantly from 10.6 +/- 2.8 cmH2O to 15.8 +/- 2.1 cmH2O, we found no increase in lymphatic driving pressure.
淋巴管在引流腹腔多余液体和预防腹水方面起着重要作用。在绵羊中，引流腹腔的膈淋巴管通向纵隔后淋巴结，该淋巴结的输出淋巴管汇入颈部的静脉。为了评估绵羊腹腔内液体过多时的淋巴液流动反应，我们对5只绵羊的纵隔后淋巴结输出淋巴管进行了插管。绵羊术后恢复后，淋巴液流量（QL）为154±161（标准差）微升/分钟，淋巴蛋白浓度（CL）为3.7±9克/分升。当淋巴流出压力大于6厘米水柱时，淋巴液流量随压力增加呈线性下降。根据QL与流出压力的这种线性关系，我们将驱动淋巴液流动的有效压力估计为QL = 0时的流出压力。在基线时，驱动压力为24.7±14.0厘米水柱。向腹腔内注入林格氏液（体重的10%）后，QL显著增加至基线的7.0±4.1倍，CL显著降低至0.7±0.6克/分升。尽管腹腔压力从10.6±2.8厘米水柱显著增加至15.8±2.1厘米水柱，但我们发现淋巴驱动压力没有增加。
