The radiation chemistry of d(CpGpTpA) in the presence of oxygen.
作者信息
Budzinski E E, Dawidzik J D, Wallace J C, Freund H G, Box H C
机构信息
Biophysics Department, Roswell Park Cancer Institute, Buffalo, New York 14263.
出版信息
Radiat Res. 1995 Apr;142(1):107-9.
PMID:7899553
Abstract
This report extends our investigation of double base lesions produced by irradiation of DNA model compounds. Studies of d(CpGpTpA) X-irradiated in oxygenated aqueous solution show that two of the five principal products are oligomers having adjacent bases damaged. In these oligomers guanine is hydroxylated at the 8-position and an adjacent pyrimidine is degraded to a formamido remnant.
摘要
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