在脱氧的d（CpGpTpA）溶液中，辐射诱导脱氧鸟苷和胸苷的碱基部分之间形成交联。
Radiation-induced formation of a crosslink between base moieties of deoxyguanosine and thymidine in deoxygenated solutions of d(CpGpTpA).
作者信息
Box H C, Budzinski E E, Dawidzik J D, Wallace J C, Evans M S, Gobey J S
机构信息
Biophysics Department, Roswell Park Cancer Institute, Buffalo, New York, 14263, USA.
出版信息
Radiat Res. 1996 May;145(5):641-3.
PMID:8619032
Abstract
A new type of tandem base lesion has been observed in d(CpGpTpA) X-irradiated in aqueous solution. The lesion is attributed to the formation of a covalent bond between the C8 carbon atom of guanine and the methyl carbon atom of thymine. This tandem base lesion is formed in the absence of oxygen. It is the main product produced by ionizing radiation under these conditions.
摘要
在水溶液中经X射线照射的d(CpGpTpA)中观察到一种新型串联碱基损伤。这种损伤归因于鸟嘌呤的C8碳原子与胸腺嘧啶的甲基碳原子之间形成了共价键。这种串联碱基损伤是在无氧条件下形成的。它是在这些条件下电离辐射产生的主要产物。
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