Protection against cisplatin lethality and renal toxicity by chlorpromazine in mice.
作者信息
Ishikawa M, Ozaki M, Takayanagi Y, Sasaki K
机构信息
Department of Pharmacology and Toxicology, Tohoku College of Pharmacy, Sendai, Japan.
出版信息
Ren Fail. 1994 Nov;16(6):681-6. doi: 10.3109/08860229409044897.
PMID:7899579
Abstract
The effect of chlorpromazine on acute lethal toxicity and nephrotoxicity induced by cisplatin was studied in mice. Chlorpromazine (i.p.) given 1 h before cisplatin greatly reduced lethal and renal toxicities of cisplatin, while chlorpromazine did not reduce the antitumor activity of cisplatin against sarcoma 180 in ddY mice or El-4 leukemia in C57BL/6J mice.
摘要
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