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氯丙嗪对顺铂所致小鼠致死性和肾毒性的保护作用。

Protection by chlorpromazine against lethality and renal toxicity of cisplatin in mice.

作者信息

Ishikawa M, Ozaki M, Takayanagi Y, Sasaki K

机构信息

Department of Pharmacology and Toxicology, Tohoku College of Pharmacy, Sendai, Japan.

出版信息

Experientia. 1992 Dec 1;48(11-12):1142-4. doi: 10.1007/BF01948009.

DOI:10.1007/BF01948009
PMID:1473580
Abstract

The effect of chlorpromazine on acute lethal toxicity and nephrotoxicity induced by cisplatin was studied in mice. Chlorpromazine given (i.p.) 1 h before cisplatin greatly reduced lethal and renal toxicities of cisplatin. Chlorpromazine did not reduce the antitumor activity of cisplatin against Sarcoma 180 in ddY mice or EL-4 Leukemia in C57BL/6J mice.

摘要

研究了氯丙嗪对顺铂诱导的小鼠急性致死毒性和肾毒性的影响。在顺铂给药前1小时腹腔注射氯丙嗪，可大大降低顺铂的致死毒性和肾毒性。氯丙嗪不会降低顺铂对ddY小鼠肉瘤180或C57BL/6J小鼠EL-4白血病的抗肿瘤活性。

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2
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