Ishikawa A, Shiono T, Uchida S
Department of Ophthalmology, Tohoku University School of Medicine, Miyagi, Japan.
Retina. 1994;14(5):435-7. doi: 10.1097/00006982-199414050-00008.
Certain aspects in the development of Vogt-Koyanagi-Harada (VKH) disease are documented, and immunogenetic studies have revealed a high relevance of some HLA types. Roles of possible environmental factors in disease onset are not fully understood, however.
Two cases involving monozygotic twin sisters who were diagnosed as having VKH disease and followed for more than 2 years are presented.
Both patients showed the diffuse panuveitis that is characteristic of VKH disease and shared the same HLA typings. However, there was a 16-year time lag between onset of disease in the two patients, and many differences in their lifestyles before disease onset were noted.
Although certain endogenous factors play an important role in the development of VKH disease, some exogenous factors may also affect the onset of the disease.
Vogt-小柳-原田（VKH）病发展过程中的某些方面已有文献记载，免疫遗传学研究表明某些HLA类型与之高度相关。然而，尚不完全清楚可能的环境因素在疾病发作中的作用。
报告了两例涉及同卵双胞胎姐妹的病例，她们被诊断为患有VKH病并随访了2年多。
两名患者均表现出VKH病特有的弥漫性全葡萄膜炎，且具有相同的HLA分型。然而，两名患者发病时间间隔16年，且注意到她们发病前的生活方式存在许多差异。
虽然某些内源性因素在VKH病的发展中起重要作用，但一些外源性因素也可能影响该病的发作。
