cDNA sequences of Schistosoma japonicum coding for two cathepsin B-like proteins and Sj32.
作者信息
Merckelbach A, Hasse S, Dell R, Eschlbeck A, Ruppel A
机构信息
Institute for Tropical Hygiene, University of Heidelberg, Germany.
出版信息
Trop Med Parasitol. 1994 Sep;45(3):193-8.
PMID:7899786
Abstract
Sequences of three cDNAs of Schistosoma japonicum are presented. Two of them code for the antigens Sj32 (hemoglobinase) and cathepsin B. The third clone represents a mutant derivative of the cathepsin B gene. The DNA and amino acid sequences are compared to their homologues from S. mansoni. The mutant cathepsin B, in which the Cys29 in the active center is replaced by Ser, is discussed with respect to a possible function.
摘要
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