Chebotar' N A, Konopistseva L A, Ignat'eva T V, Golinskiĭ G F, Puchkov V F, Dyban A P
Tsitol Genet. 1994 Sep-Oct;28(5):77-80.
Against the background of the induced iron deficit ethanol (6.4 g/kg) causes aggravation of the embryolethal effect and anomalies in 15% of embryos in 14-day pregnant rats. Changes in the genome of rat males and females after the injection of the plasmid with a foreign gene at the stage of two pronuclei and the subsequent crossing with intact animals account for the increase in sensitivity of embryos to subteratogenic doses of sodium salicilate. The maternal organism disturbances have a more pronounced effect than the paternal ones.
在诱导铁缺乏的背景下，乙醇（6.4克/千克）会使妊娠14天的大鼠胚胎致死效应加重，15%的胚胎出现异常。在双原核阶段注射携带外源基因的质粒后，大鼠雄性和雌性基因组发生变化，随后与未处理动物交配，这导致胚胎对亚致畸剂量的水杨酸钠敏感性增加。母体机体紊乱的影响比父体的更明显。
