Gordeĭchuk T N, Chebotar' N A, Konopistseva L A, Puchkov V F
Ontogenez. 1993 Jan-Feb;24(1):48-55.
Preventive administration of Eleutherococcus XXX extract during prenatal and pre-embryonic periods of development prevents embryotoxic effect of subsequent treatment of pregnant rats with ethanol and sodium salicylate. Eleutherococcus abolishes embryotoxic and teratogenic effects of ethanol manifested against the background of experimental syndrome of iron deficit in pregnant females. Mechanism of its antiteratogenic action is probably based on stimulation of cell detoxification mechanisms, increase in energy potential of cells, as well as on stabilization of structural and functional state of cell membranes.
在产前和胚胎前期发育阶段预防性给予刺五加XXX提取物，可预防乙醇和水杨酸钠对怀孕大鼠后续处理产生的胚胎毒性作用。刺五加消除了在怀孕雌性大鼠铁缺乏实验综合征背景下出现的乙醇胚胎毒性和致畸作用。其抗致畸作用机制可能基于对细胞解毒机制的刺激、细胞能量潜力的增加以及细胞膜结构和功能状态的稳定。
