Zhad'ko S I
Lik Sprava. 1994 Jul-Aug(7-8):128-30.
Local fibrinolysis was studied of oral cavity in healthy individuals (n = 20) and in patients suffering from inflammatory changes in the mucous membrane of the oral cavity (n = 23). Comparison of the results was done with reference to the indicators of the systemic fibrinolysis activity in the same persons. There has been revealed a definite fibrinolytic activity of saliva, particularly its mucinous component. In healthy subjects it is significantly higher as compared to the patients. The local fibrinolysis is provided by the activator of plasminogen rather than the enzyme plasmin. The mucous membrane of the oral cavity does not possess physiologically significant activity since the tissue activator of plasminogen it contains is extracted with 2M solution of potassium thiocyanate only. No shifts of systemic fibrinolytic potential have been revealed in inflammatory changes of the mucous membrane.
对20名健康个体和23名患有口腔黏膜炎症性病变的患者的口腔局部纤溶作用进行了研究。参照同一人群的全身纤溶活性指标对结果进行了比较。已发现唾液，尤其是其黏液成分具有一定的纤溶活性。与患者相比，健康受试者中的该活性显著更高。局部纤溶作用是由纤溶酶原激活剂而非纤溶酶提供的。口腔黏膜不具有生理上显著的活性，因为其所含的纤溶酶原组织激活剂仅能用2M硫氰酸钾溶液提取。在黏膜的炎症性变化中未发现全身纤溶潜力的改变。
