Tsugaya M, Hayashi Y, Sasaki S, Kojima Y, Kohri K, Mogami T, Fushimi N
Department of Urology, Nagoya City University, Medical School.
Hinyokika Kiyo. 1995 Jan;41(1):51-5.
A 2-month-old girl having a left multicystic dysplastic kidney with contralateral mild hydronephrosis is described. Furosemide was administered orally because of hyperpotassemia during the period between 1 month and 7 months of age. Peripheral plasma renin activity and plasma aldosterone activity increased at the age of 6 months, and ultimately reached the peak at 9 days after discontinuation of furosemide at the age of 7 months. Peripheral plasma renin activity and plasma aldosterone activity were normalized at the age of 11 months. Blood pressure during the whole period was normal. Contralateral hydronephrosis was improved gradually. The level of serum creatinine became normal at the age of 50 days. A case with a high level of plasma renin and aldosterone activity temporarily induced by furosemide was reported. Pathophysiology of pseudo-Bartter syndrome without hypopotassemia due to furosemide is discussed.
本文描述了一名2个月大的女童，其左侧为多囊性发育不良肾，对侧有轻度肾积水。该女童在1至7个月龄期间因高钾血症口服了速尿。外周血浆肾素活性和血浆醛固酮活性在6个月龄时升高，并在7个月龄停用速尿9天后最终达到峰值。外周血浆肾素活性和血浆醛固酮活性在11个月龄时恢复正常。整个期间血压正常。对侧肾积水逐渐改善。血清肌酐水平在50天时恢复正常。报告了一例由速尿暂时诱导的血浆肾素和醛固酮活性升高的病例。并讨论了速尿所致无低钾血症的假性巴特综合征的病理生理学。
