Dhar K K, Dhall G I, Ayyagari A
Department of Obstetrics & Gynaecology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Int J Gynaecol Obstet. 1993 Aug;42(2):117-20. doi: 10.1016/0020-7292(93)90623-5.
To determine the efficacy and side effects of a single dose of tinidazole for infection following vaginal hysterectomy.
A randomized double-blind placebo-controlled trial using 2 g tinidazole 12 h before vaginal hysterectomy in 50 patients was conducted. No other antibiotic was used until the development of infection.
There was a significant reduction (P < 0.01) of post-operative vaginal cuff cellulitis (54-16%). A similar reduction (P < 0.05) in febrile morbidity was also observed. The duration of postoperative hospital stay (P < 0.001) and use of additional antibiotics (P < 0.01) were also reduced. No adverse effect of tinidazole was noted.
A single dose of tinidazole appears to be a safe and effective alternative prevention against infection in vaginal hysterectomy.
