Crosthwaite A H, Hurse A B, McDonald I A, Miles H M, Pavillard E R
Aust N Z J Obstet Gynaecol. 1985 Feb;25(1):55-8. doi: 10.1111/j.1479-828x.1985.tb00604.x.
The results of this randomized double blind, placebo controlled trial of a single oral dose of 2 g tinidazole or placebo approximately 12 hours before hysterectomy showed the incidence of infective morbidity in patients who received placebo was 12.2% compared with 1.9% in patients who received tinidazole, (p = 0.045). The mean serum concentration of tinidazole at the time of surgery was 35 mcg/ml, which was well in excess of the minimum concentration required to inhibit all of the 95 anaerobes isolated in this study. Serum tinidazole concentration remained adequately inhibitory for at least 24 hours after surgery. The ability of tinidazole prophylaxis to reduce further our already low rate of febrile morbidity was considered a worthwhile gain. It is now Unit policy to give this agent prophylactically to all patients if the integrity of the vagina is likely to be breached at the time of surgery.
这项随机双盲、安慰剂对照试验的结果显示，在子宫切除术前约12小时单次口服2克替硝唑或安慰剂。接受安慰剂的患者感染性发病的发生率为12.2%，而接受替硝唑的患者为1.9%，（p = 0.045）。手术时替硝唑的平均血清浓度为35微克/毫升，远远超过抑制本研究中分离出的所有95种厌氧菌所需的最低浓度。术后至少24小时，血清替硝唑浓度仍保持足够的抑制作用。替硝唑预防措施能够进一步降低我们本已较低的发热发病率，这被认为是一项有价值的收获。如果手术时阴道完整性可能被破坏，现在该科室的政策是对所有患者进行预防性使用这种药物。
