McDonald P J, Sanders T, Higgins G, Finlay-Jones L, Hakendorf M, Turnidge J, Jones W
J Antimicrob Chemother. 1984 Sep;14 Suppl B:223-30. doi: 10.1093/jac/14.suppl_b.223.
The role of prophylactic cefotaxime and a combination of ampicillin and tinidazole was assessed in 201 patients undergoing hysterectomy. One hundred and twenty-five patients were evaluated in the abdominal hysterectomy group and 46 patients completed the protocol after vaginal hysterectomy. Patients were allocated randomly to receive either (1) no prophylactic antibiotic, (2) cefotaxime peroperatively for 24 h or (3) ampicillin/tinidazole peroperatively for 24 h. Both cefotaxime and ampicillin/tinidazole reduced the septic complication rate in abdominal and vaginal hysterectomy. Efficacy was most evident in reducing early urinary infections after abdominal hysterectomy (0.001 less than P less than 0.01). Cefotaxime and ampicillin/tinidazole were equally effective and no significant side-effects were demonstrated. Cefotaxime is recommended as a safe and effective agent for hysterectomy prophylaxis.
对201例行子宫切除术的患者评估了预防性使用头孢噻肟以及氨苄西林与替硝唑联合使用的作用。125例患者纳入腹式子宫切除术组进行评估，46例患者在阴式子宫切除术后完成了方案。患者被随机分配接受以下治疗：（1）不使用预防性抗生素；（2）术中使用头孢噻肟24小时；（3）术中使用氨苄西林/替硝唑24小时。头孢噻肟和氨苄西林/替硝唑均降低了腹式和阴式子宫切除术的感染并发症发生率。在降低腹式子宫切除术后早期泌尿系统感染方面疗效最为明显（0.001＜P＜0.01）。头孢噻肟和氨苄西林/替硝唑效果相当，且未显示出明显的副作用。推荐头孢噻肟作为子宫切除术预防用药的一种安全有效的药物。
