携带感染性病毒的外周血单个核细胞高浓度与1型人类免疫缺陷病毒相关疾病的快速进展相关。

High concentration of peripheral blood mononuclear cells harboring infectious virus correlates with rapid progression of human immunodeficiency virus type 1-related diseases.

作者信息

Lu W, Grassi F, Tourani J M, Eme D, Israel-Biet D, Andrieu J M

机构信息

Laboratory of Tumor Immunology, Hôpital Laënnec, Université de Paris V, France.

出版信息

J Infect Dis. 1993 Nov;168(5):1165-8. doi: 10.1093/infdis/168.5.1165.

DOI:10.1093/infdis/168.5.1165

PMID:7901285

Abstract

In a cohort of 103 asymptomatic seropositive subjects (Centers for Disease Control and Prevention [CDC] stage II/III) followed for 2 years, the concentration of peripheral blood mononuclear cells harboring infectious human immunodeficiency virus (HIV) type 1 (viral burden) was correlated with the rate of decrease of CD4 cell count (RD-CD4; R = .857). Rapidly progressing patients (RD-CD4 > or = 60%; n = 18) had a high viral burden (mean +/- SE, 572 +/- 202 cells/mL) and an 89% progression to CDC IV-A-C, while stable patients (RD-CD4 < 30%; n = 55) had a low viral burden (mean +/- SE, 28 +/- 4 cells/mL) and remained asymptomatic. Slowly progressing patients (RD-CD4 > or = 30 and < 60%; n = 30) showed an intermediate viral burden (mean +/- SE, 131 +/- 9 cells/mL) and a 10% CDC IV-A-C progression. Quantitative determination of infectious virus in blood cells adds important information on the prognosis of HIV-1 infection.

摘要

在一组103名无症状血清反应阳性受试者（疾病控制和预防中心[CDC]II/III期）中进行了为期2年的随访，携带1型感染性人类免疫缺陷病毒（HIV）的外周血单个核细胞浓度（病毒载量）与CD4细胞计数下降率（RD-CD4；R = 0.857）相关。快速进展患者（RD-CD4≥60%；n = 18）病毒载量高（平均值±标准误，572±202个细胞/毫升），89%进展为CDC IV-A-C期，而稳定患者（RD-CD4 < 30%；n = 55）病毒载量低（平均值±标准误，28±4个细胞/毫升）且仍无症状。缓慢进展患者（RD-CD4≥30%且< 60%；n = 30）显示出中等病毒载量（平均值±标准误，131±9个细胞/毫升），10%进展为CDC IV-A-C期。血细胞中感染性病毒的定量测定为HIV-1感染的预后增添了重要信息。