Sturgess R P, Loft D, Kontakou M, Crowe P, Marsh M N, Ciclitira P J
Rayne Institute, St Thomas's Hospital, London, UK.
Scand J Gastroenterol. 1993 Sep;28(9):760-2. doi: 10.3109/00365529309104004.
The proportion of intra-epithelial lymphocytes (IEL) that utilize the gamma/delta form of the T-cell receptor (TCR) is increased in coeliac disease, but their function remains unexplained. The response of intra-epithelial lymphocytes to rectal gluten challenge in coeliac and control subjects was studied after a rectal challenge of 2 g of Frazer's fraction III. A marked rise in CD3+ IEL occurred after challenge in the coeliac patients, peaking at 6 h and returning to normal by 48 h, with no significant changes in the gamma/delta TCR+ IEL. The IEL did not significantly change after gluten challenge in the controls. Acute gluten challenge induces infiltration of the rectal mucosa by T cells in coeliac patients, which is not accompanied acutely by increased numbers of gamma/delta TCR+ IEL. This study supports the hypothesis that alpha/beta TCR+ T cells may be of importance in the early response of coeliac patients to local gluten challenge.
乳糜泻患者中利用γ/δ形式的T细胞受体（TCR）的上皮内淋巴细胞（IEL）比例增加，但其功能仍不清楚。在给予2g弗雷泽III级组分进行直肠激发后，研究了乳糜泻患者和对照受试者的上皮内淋巴细胞对直肠麸质激发的反应。乳糜泻患者激发后CD3⁺ IEL显著升高，在6小时达到峰值，48小时恢复正常，γ/δ TCR⁺ IEL无显著变化。对照组麸质激发后IEL无显著变化。急性麸质激发可诱导乳糜泻患者直肠黏膜T细胞浸润，急性期间γ/δ TCR⁺ IEL数量无增加。本研究支持以下假说：α/β TCR⁺ T细胞可能在乳糜泻患者对局部麸质激发的早期反应中起重要作用。
