Matsui T, Hirai M, Hirano M, Kurosawa Y
Institute for Comprehensive Medical Science, Fujita Health University, Aichi, Japan.
FEBS Lett. 1993 Dec 20;336(1):107-10. doi: 10.1016/0014-5793(93)81620-f.
Two newly identified human homeobox-containing genes, GBX1 and GBX2, are closely related genes, as are members of the other homeobox genes, EN-1 and EN-2. GBX1 and EN-2 have been mapped to chromosome 7q36. The present study shows that GBX2 was mapped to chromosome 2q37. EN-1 was mapped to chromosome 2q14. Moreover, two HOX complexes neighbored by the EVX gene, HOXA and HOXD, are located at chromosome 7p15-p14 and 2q31-q37, respectively. Thus, it is possible that these homeobox genes were linked to each other on an ancestral genome and that the ancestral chromosome segment was duplicated during evolution.
两个新发现的含人类同源框基因GBX1和GBX2是紧密相关的基因，其他同源框基因的成员EN-1和EN-2也是如此。GBX1和EN-2已被定位到7号染色体的q36区域。本研究表明，GBX2被定位到2号染色体的q37区域。EN-1被定位到2号染色体的q14区域。此外，由EVX基因相邻的两个HOX复合体HOXA和HOXD分别位于7号染色体的p15-p14区域和2号染色体的q31-q37区域。因此，这些同源框基因有可能在祖先基因组上相互连锁，并且祖先染色体片段在进化过程中发生了复制。
