Queiroz D M, Mendes E N, Rocha G A, Moura S B, Resende L M, Barbosa A J, Coelho L G, Passos M C, Castro L P, Oliveira C A
Laboratory of Research in Bacteriology, Faculty of Medicine, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Scand J Gastroenterol. 1993 Oct;28(10):858-64. doi: 10.3109/00365529309103125.
The density of antral gastrin (G)- and somatostatin (D)-immunoreactive cells and the contents of antral gastrin and somatostatin were investigated in endoscopic antral biopsy specimens from patients with duodenal ulcer before and after eradication of Helicobacter pylori. After H. pylori eradication both antral somatostatin concentration (p = 0.0002) and antral D-cell density (p = 0.01) increased significantly. Conversely, although the number of G-cells was unchanged, antral (p = 0.0002) and serum (p = 0.001) gastrin contents decreased significantly. The number of oxyntic D-cells did not change significantly. These results strongly suggest that the hypergastrinaemia observed in H. pylori-positive patients may be due to a deficiency in antral somatostatin, which normally inhibits the synthesis and release of gastrin.
在幽门螺杆菌根除前后，对十二指肠溃疡患者的内镜下胃窦活检标本中胃窦胃泌素（G）和生长抑素（D）免疫反应性细胞的密度以及胃窦胃泌素和生长抑素的含量进行了研究。根除幽门螺杆菌后，胃窦生长抑素浓度（p = 0.0002）和胃窦D细胞密度（p = 0.01）均显著增加。相反，虽然G细胞数量未变，但胃窦（p = 0.0002）和血清（p = 0.001）胃泌素含量显著降低。胃底D细胞数量无显著变化。这些结果有力地表明，幽门螺杆菌阳性患者中观察到的高胃泌素血症可能是由于胃窦生长抑素缺乏所致，而生长抑素通常会抑制胃泌素的合成和释放。
