Qin L, Chavin K D, Lin J, Yagita H, Bromberg J S
Department of Surgery, Medical University of South Carolina, Charleston 29425.
J Exp Med. 1994 Jan 1;179(1):341-6. doi: 10.1084/jem.179.1.341.
Indefinite graft survival was obtained with murine cardiac allografts using the combined administration of monoclonal antibodies (mAbs) directed against the receptor ligand pair CD2-CD48. Although each antibody could prolong graft survival when given alone, neither resulted in the indefinite graft survival seen with the combination. Combined mAb administration is associated with inhibition of T cell priming and help and subsequent cytotoxic T lymphocyte generation. This indicates that the interaction between CD2 and its ligand is important for antigen priming and recognition, and combined mAbs may prove to be a useful therapeutic regimen for transplantation.
通过联合给予针对受体配体对CD2 - CD48的单克隆抗体（mAb），小鼠心脏同种异体移植获得了无限期的移植物存活。尽管每种抗体单独使用时都可以延长移植物存活时间，但单独使用都不会产生联合使用时所见到的无限期移植物存活。联合给予单克隆抗体与抑制T细胞致敏、辅助以及随后细胞毒性T淋巴细胞的产生有关。这表明CD2与其配体之间的相互作用对于抗原致敏和识别很重要，联合单克隆抗体可能被证明是一种有用的移植治疗方案。
