Roy A
Neuropsychobiology. 1993;28(4):184-6. doi: 10.1159/000119021.
Neuropeptides were examined in relation to suicidal behavior and its repetition in depression. There were no significant differences between depressed patients who had or had not attempted suicide for cerebrospinal fluid (CSF) concentrations of neuropeptide Y, somatostatin, diazepam-binding inhibitor, GABA, or corticotropin releasing hormone. A 5-year follow-up was carried out. There were no significant differences between depressed patients who did or did not reattempt suicide during the follow-up or who had never attempted for CSF concentrations of any of the neuropeptides measured. These negative results suggest that these neuropeptides are probably not major determinants of suicidal behavior or its repetition in depression.
研究了与自杀行为及其在抑郁症中的复发相关的神经肽。对于脑脊液中神经肽Y、生长抑素、地西泮结合抑制剂、γ-氨基丁酸或促肾上腺皮质激素释放激素的浓度，有自杀未遂和无自杀未遂的抑郁症患者之间没有显著差异。进行了为期5年的随访。在随访期间有或没有再次自杀企图的抑郁症患者之间，或从未有过自杀企图的抑郁症患者之间，所测量的任何神经肽的脑脊液浓度均无显著差异。这些阴性结果表明，这些神经肽可能不是自杀行为及其在抑郁症中复发的主要决定因素。
