Rodríguez A D, Acosta A L, Dhasmana H
University of Puerto Rico, Department of Chemistry, Río Piedras 00931-3346.
J Nat Prod. 1993 Oct;56(10):1843-9. doi: 10.1021/np50100a031.
The dolabellane diterpenoid palominol [1] was reisolated from the Caribbean gorgonian Eunicea laciniata and subjected to a total structural assignment through the application of several 2D nmr techniques that included COSY, ROESY, INADEQUATE, HMQC, and proton-detected long-range heteronuclear chemical shift correlation (HMBC). The revised structure of palominol proposed by Shin and Fenical was rigorously confirmed by these methods. The unequivocal assignments of the 1H- and 13C-nmr spectra of palominol are reported. A new diterpenoid, isopalominol [5], also of the dolabellane class, has been isolated from the same specimen of Eu. laciniata and its structure defined by combined spectral and chemical methods.
从加勒比海柳珊瑚Eunicea laciniata中重新分离出多拉贝拉二萜类化合物帕洛米诺醇[1]，并通过应用包括COSY、ROESY、INADEQUATE、HMQC和质子检测的远程异核化学位移相关（HMBC）在内的几种二维核磁共振技术对其进行了全结构归属。Shin和Fenical提出的帕洛米诺醇的修订结构通过这些方法得到了严格证实。报道了帕洛米诺醇的1H和13C核磁共振谱的明确归属。一种新的二萜类化合物，异帕洛米诺醇[5]，也属于多拉贝拉类，已从同一Eunicea laciniata标本中分离出来，并通过光谱和化学方法相结合确定了其结构。
