Rump A F, Rösen R, Klaus W
Institut für Pharmakologie, Universität Köln, Germany.
Naunyn Schmiedebergs Arch Pharmacol. 1993 Oct;348(4):431-4. doi: 10.1007/BF00171344.
Several beta-adrenoceptor-blocking agents have been shown to possess free radical scavenging properties. Therefore, the direct cardioprotective properties of propranolol or pindolol were investigated in comparison to superoxide dismutase (SOD). We used isolated rabbit hearts paced at a constant rate (Langendorff, constant pressure: 70 cm H2O, Tyrode solution, Ca2+ 1.8 mmol/l). Acute regional myocardial ischemia (MI) was induced by left coronary artery branch occlusion and quantitated from epicardial NADH-fluorescence photography. Propranolol (10(-8) mol/l), pindolol (10(-6) mol/l) or SOD (48 I.U./ml) had no significant influence on left ventricular pressure, pressure-rate product or global coronary flow (p > 0.05). Whereas epicardial NADH-fluorescence area after repetitive coronary occlusions was significantly diminished by SOD-treatment (-25%) (p < 0.05), MI size was not significantly affected by either propranolol or pindolol (p > 0.05).
Oxygen-derived free radicals contribute to tissue injury during myocardial ischemia, and propranolol or pindolol do not possess free radical scavenging properties relevant for cardioprotection in a repetitive coronary occlusion model in isolated rabbit hearts.
几种β-肾上腺素受体阻滞剂已被证明具有清除自由基的特性。因此，将普萘洛尔或吲哚洛尔的直接心脏保护特性与超氧化物歧化酶（SOD）进行了比较研究。我们使用以恒定速率起搏的离体兔心脏（Langendorff法，恒定压力：70 cm H₂O，台氏液，Ca²⁺ 1.8 mmol/L）。通过左冠状动脉分支闭塞诱导急性局部心肌缺血（MI），并通过心外膜NADH荧光摄影进行定量分析。普萘洛尔（10⁻⁸ mol/L）、吲哚洛尔（10⁻⁶ mol/L）或SOD（48 IU/ml）对左心室压力、压力-速率乘积或冠状动脉总血流量均无显著影响（p > 0.05）。虽然重复冠状动脉闭塞后的心外膜NADH荧光面积经SOD处理后显著减小（-25%）（p < 0.05），但MI大小不受普萘洛尔或吲哚洛尔的显著影响（p > 0.05）。
氧衍生自由基在心肌缺血期间导致组织损伤，在离体兔心脏重复冠状动脉闭塞模型中，普萘洛尔或吲哚洛尔不具有与心脏保护相关的自由基清除特性。
